We demonstrate time domain diffuse correlation spectroscopy at quasi-null source-detector separation by using a fast time-gated single-photon avalanche diode without the need of time-tagging electronics. This approach allows for increased photon collection, simplified real-time instrumentation, and reduced probe dimensions. Depth discriminating, quasi-null distance measurement of blood flow in a human subject is presented. We envision the miniaturization and integration of matrices of optical sensors of increased spatial resolution and the enhancement of the contrast of local blood flow changes. © 2018 Optical Society of America

In vivo time-gated diffuse correlation spectroscopy at quasi-null source-detector separation

Konugolu Venkata Sekar, S.;Sieno, L. D. I.;Colombo, L.;Contini, D.;Torricelli, A.;Pifferi, A.;Dalla Mora, A.
2018

Abstract

We demonstrate time domain diffuse correlation spectroscopy at quasi-null source-detector separation by using a fast time-gated single-photon avalanche diode without the need of time-tagging electronics. This approach allows for increased photon collection, simplified real-time instrumentation, and reduced probe dimensions. Depth discriminating, quasi-null distance measurement of blood flow in a human subject is presented. We envision the miniaturization and integration of matrices of optical sensors of increased spatial resolution and the enhancement of the contrast of local blood flow changes. © 2018 Optical Society of America
Avalanche photodiodes, Photon migration, Time-resolved imaging, Medical optics instrumentation.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/1064744
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