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Catalogo Pubblicazioni POLIMI: [186079] Home page macrotipologia

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Noninvasive Markers of Macrophage Polarization via Multimodal Nonlinear Optical Microscopy

Tumor associated macrophages (TAMs) are pivotal in the tumor microenvironment, influencing angiogenesis, metastasis, and immunosuppression. This study explores macrophage polarization using a noninvasive, label free multimodal nonlinear optical approach, combining Stimulated Raman Scattering and Two-Photon Excited Fluorescence microscopy. By investigating murine TAMs, we identify distinct polarization states (M0, M1, and M2) through marker free vibrational and autofluorescence signatures. Our...

Broadband CARS microscopy of biological samples

Coherent anti-Stokes Raman Scattering (CARS) microscopy is a label-free vibrational imaging technique that delivers chemical maps of cells and tissues. Broadband CARS (BCARS) combines narrowband pump pulses with broadband Stokes pulses to record broad vibrational spectra. Despite many technological advancements, BCARS microscopes still struggle to image biological samples spanning the entire Raman active region of biological samples (400-3100 cm-1). Here, we demonstrate a novel BCARS method t...

High-rejection birefringent filter for Brillouin mechanical imaging in turbid media

Non-contact Brillouin microscopy holds potential to become an essential tool for mechanobiology, yet this method faces challenges in turbid samples as a consequence of strong Rayleigh scattering. Here, we introduce a common-path birefringence-induced phase delay (BIPD) filter exhibiting an extinction ratio of 65 dB in a single-pass configuration. We demonstrate the capability of the filter to acquire Brillouin maps in turbid samples such as bone tissues of a mouse model of osteopetrosis, a ra...

Micro-Fabricated Optics for Multiphoton Microscopy

We report new methods of 2 photon polymerization of microlenses with high numerical aperture, large diameter and good optical quality. We characterize the aberrations of these lenses that, coupled to raster scanning optical microscopes, allow two-photon excitation imaging of cells. In-vivo non-linear imaging will be also discussed, opening the possibility to use these micro-lenses in implants for the continuous inspection of biological dynamics in vivo.

Multimodal multiphoton and vibrational microscopy reveals early therapy-induced senescence in human tumors: a non-invasive tool to prevent the risk of cancer relapse

Recent studies have shown that common anticancer treatments can induce cell senescence rather than death, a critical phenotype governing tumor recurrence. This calls for the urgent development of safe, precise, and quick tools to unveil critical therapy-induced senescence (TIS). Merging different coherent Raman and multiphoton techniques, we present label-free multimodal nonlinear optical (NLO) microscopy as a powerful tool to spot early TIS. We home-built a microscope including different NLO...

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Tipologia
  • 01 CONTRIBUTO SU RIVISTA80560
  • 04 CONTRIBUTO IN ATTI DI CONVEGNO63735
  • 02 CONTRIBUTO IN VOLUME27956
  • 03 LIBRO4772
  • 07 ALTRO3403
  • 06 CURATELA3291
  • 05 BREVETTO2365
Autore
  • ZIO, ENRICO1452
  • CERULLO, GIULIO NICOLA FELICE933
  • SAVARESI, SERGIO MATTEO751
  • MILANI, GABRIELE749
  • RESNATI, GIUSEPPE662
  • FABRIS, LUCA MARIA FRANCESCO636
  • FIORINI, CARLO ETTORE632
  • FORZATTI, PIO626
  • KARIMI, HAMID REZA623
  • CAPOLONGO, STEFANO619
Data di pubblicazione
  • In corso di stampa188
  • 2020 - 202541996
  • 2010 - 201973783
  • 2000 - 200954681
  • 1990 - 199911826
  • 1980 - 19893017
  • 1970 - 1979569
  • 1965 - 196917
Editore
  • Springer2757
  • Institute of Electrical and Elect...2630
  • IEEE1723
  • Franco Angeli1424
  • Maggioli Editore1219
  • Maggioli1072
  • Elsevier586
  • Springer Verlag565
  • SPIE461
  • IEEE Computer Society454
Rivista
  • TERRITORIO1047
  • ARKETIPO679
  • CASABELLA588
  • DOMUS559
  • ABITARE513
  • COSTRUIRE432
  • NUCLEAR INSTRUMENTS & METHODS IN ...357
  • JOURNAL OF PHYSICS. CONFERENCE SE...349
  • ANANKE338
  • OPTICS LETTERS320
Serie
  • LECTURE NOTES IN COMPUTER SCIENCE414
  • IFAC-PAPERSONLINE312
  • POLITECNICA306
  • INTERNATIONAL ASTRONAUTICAL CONGR...279
  • PROCEEDINGS OF SPIE, THE INTERNAT...253
  • RESEARCH FOR DEVELOPMENT250
  • LECTURE NOTES IN CIVIL ENGINEERING233
  • SPRINGERBRIEFS IN APPLIED SCIENCE...182
  • LECTURE NOTES IN ARTIFICIAL INTEL...161
  • ADVANCES IN THE ASTRONAUTICAL SCI...147
Keyword
  • sezele2337
  • INF1532
  • Electrical and Electronic Enginee...1368
  • AUT1141
  • Mechanical Engineering982
  • Computer Science Applications1707...763
  • architettura697
  • Milano682
  • Industrial and Manufacturing Engi...662
  • Control and Systems Engineering637
Lingua
  • eng120487
  • ita41947
  • fre734
  • spa697
  • Inglese549
  • Italiano512
  • ger387
  • chi274
  • por231
  • rus114
Accesso al fulltext
  • no fulltext84649
  • reserved61270
  • open33051
  • partially open6880
  • embargoed173
  • mixed56