In this paper we demonstrate the advantages of a fast-gated counter in achieving high count rate and reducing costs of timing equipment in a time-resolved diffuse optical spectroscopy setup. We experimentally prove the equivalence between the fast-gated counter we developed and a traditional time-correlated single-photon counting setup in terms of depth sensitivity and signal-to-noise ratio. Additionally, we show the suitability of this device for bilayer analysis and to estimate the absorption coefficient of homogeneous diffusing media. Finally, we present a proof-of-principle arterial occlusion measurement on a healthy volunteer to validate the proposed approach in a real application. Fast-gated counters can dramatically reduce both costs and complexity in time-resolved multichannel systems, while achieving high count rate, thus offering a great advantage in applications like brain and muscle functional imaging.

Diffuse optics using a dual window fast-gated counter

DI SIENO, LAURA;DALLA MORA, ALBERTO;TOSI, ALBERTO;PIFFERI, ANTONIO GIOVANNI;CUBEDDU, RINALDO;CONTINI, DAVIDE
2014-01-01

Abstract

In this paper we demonstrate the advantages of a fast-gated counter in achieving high count rate and reducing costs of timing equipment in a time-resolved diffuse optical spectroscopy setup. We experimentally prove the equivalence between the fast-gated counter we developed and a traditional time-correlated single-photon counting setup in terms of depth sensitivity and signal-to-noise ratio. Additionally, we show the suitability of this device for bilayer analysis and to estimate the absorption coefficient of homogeneous diffusing media. Finally, we present a proof-of-principle arterial occlusion measurement on a healthy volunteer to validate the proposed approach in a real application. Fast-gated counters can dramatically reduce both costs and complexity in time-resolved multichannel systems, while achieving high count rate, thus offering a great advantage in applications like brain and muscle functional imaging.
Avalanche photodiodes; Turbid media; Time-resolved imaging; Light propagation in tissues; photon counting; sezele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/848937
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