the syntheses of new optically pure poly-halo and poly-fluoro oxiranes5b-e by addition of diazomethane on the corresponding β-keto gamma-fluorosubstituted sulphoxide intermediates, both in keto 3, hydrate 4 or in keto/ hydrate form are described. Syntheses of sulphur-free fluorinated oxiranes 18b-e, β-hydroxy-β-trifluoromethyl amine 21d, α- acid 25d and β,γ-dihydroxy-β-trifluoro- and -chlorodifluoromethyl amines 26c and 26d are shown as examples of their chemical versatility
NEW FLUORINATED CHIRAL SYNTHONS
BRAVO, PIERFRANCESCO;FRIGERIO, MASSIMO;MEILLE, STEFANO VALDO;
1994-01-01
Abstract
the syntheses of new optically pure poly-halo and poly-fluoro oxiranes5b-e by addition of diazomethane on the corresponding β-keto gamma-fluorosubstituted sulphoxide intermediates, both in keto 3, hydrate 4 or in keto/ hydrate form are described. Syntheses of sulphur-free fluorinated oxiranes 18b-e, β-hydroxy-β-trifluoromethyl amine 21d, α- acid 25d and β,γ-dihydroxy-β-trifluoro- and -chlorodifluoromethyl amines 26c and 26d are shown as examples of their chemical versatilityFile in questo prodotto:
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