A Multi-Channel Low-Power System-on-Chip for in vivo NeuralSpike Recording

This paper reports a multi-channel neural spike recording system-on-chip (SoC) with digital data compression and wireless telemetry. The circuit consists of a 64-channel low-power low-noise analog front-end, a single 8-bit analog-todigital converter (ADC), followed by digital signal compression and transmission units. The 400-MHz transmitter employs a Manchester-Coded Frequency Shift Keying (MC-FSK) modulator with low modulation index. In this way a 1.25-Mbit/s data rate is delivered within a band of about 3 MHz. Compression of the raw data is implemented by detecting the action potentials (APs) and storing 20 samples for each spike waveform. The choice greatly improves data quality and allows single neuron identification. A larger than 10-m transmission range is reached with an overall power consumption of 17.2 mW. This figure translates into a power budget of 269 μW per channel, which is in line with the results in literature but allowing a larger transmission distance and more efficient wireless link bandwidth occupation. The implemented IC was mounted on a small and light printed circuit board to be used during neuroscience experiments with freely-behaving rats. Powered by 2 AAA batteries the system can work continuously for more than 100 hours allowing long-lasting neural spike recordings.