The relative stereochemistry of the four stereocentres of spirolaxine 1, a bioactive 6,5-spiroacetal phthalide secondary metabolite, was determined through single-crystal X-ray analysis. Its absolute configuration was determined by circular dichroism; the experimental spectrum of spirolaxine is in good agreement with that evaluated by means of DeVoe coupled-oscillator calculations.

Absolute Configuration of the Fungal Metabolite Spirolaxine

MALPEZZI, LUCIANA;MEILLE, STEFANO VALDO;
2005-01-01

Abstract

The relative stereochemistry of the four stereocentres of spirolaxine 1, a bioactive 6,5-spiroacetal phthalide secondary metabolite, was determined through single-crystal X-ray analysis. Its absolute configuration was determined by circular dichroism; the experimental spectrum of spirolaxine is in good agreement with that evaluated by means of DeVoe coupled-oscillator calculations.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/567995
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