A mixture of D-alloisoleucine and L-isoleucine derivatives are selectively hydrolysed by enzymatic catalysis (alcalase) allowing the recovery of the D-allo stereoisomer in excellent d.e. and yields. Thus, N-formyl-D-allo-isoleucine benzylester is obtained after enzymatic hydrolysis of the diastereoisomeric mixture or by a crystallisation procedure. (C) 2003 Elsevier Ltd. All rights reserved.
Chemo-enzymatic approach to D-allo-isoleucine
D'ARRIGO, PAOLA;FASOLI, EZIO;SERVI, STEFANO;TESSARO, DAVIDE;
2003-01-01
Abstract
A mixture of D-alloisoleucine and L-isoleucine derivatives are selectively hydrolysed by enzymatic catalysis (alcalase) allowing the recovery of the D-allo stereoisomer in excellent d.e. and yields. Thus, N-formyl-D-allo-isoleucine benzylester is obtained after enzymatic hydrolysis of the diastereoisomeric mixture or by a crystallisation procedure. (C) 2003 Elsevier Ltd. All rights reserved.File in questo prodotto:
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