A mixture of D-alloisoleucine and L-isoleucine derivatives are selectively hydrolysed by enzymatic catalysis (alcalase) allowing the recovery of the D-allo stereoisomer in excellent d.e. and yields. Thus, N-formyl-D-allo-isoleucine benzylester is obtained after enzymatic hydrolysis of the diastereoisomeric mixture or by a crystallisation procedure. (C) 2003 Elsevier Ltd. All rights reserved.

Chemo-enzymatic approach to D-allo-isoleucine

D'ARRIGO, PAOLA;FASOLI, EZIO;SERVI, STEFANO;TESSARO, DAVIDE;
2003

Abstract

A mixture of D-alloisoleucine and L-isoleucine derivatives are selectively hydrolysed by enzymatic catalysis (alcalase) allowing the recovery of the D-allo stereoisomer in excellent d.e. and yields. Thus, N-formyl-D-allo-isoleucine benzylester is obtained after enzymatic hydrolysis of the diastereoisomeric mixture or by a crystallisation procedure. (C) 2003 Elsevier Ltd. All rights reserved.
File in questo prodotto:
File Dimensione Formato  
Chemo-enzymatic approach to D-allo-isoleucine.pdf

Accesso riservato

: Altro materiale allegato
Dimensione 237.19 kB
Formato Adobe PDF
237.19 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/556877
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 10
social impact