A new enzymatic synthesis of a,b-dipeptides has been developed with particular focus on the preparation of carnosine (b-alanyl-a-histidine) and analogues. The lipase PS-D from Burkholderia cepacia has been used as a catalyst for the formation of the peptide bond starting from a b-lactam and a protected a-amino acid.
Enzymatic synthesis of carnosine derivatives catalysed by Burkholderia cepacia lipase
D'ARRIGO, PAOLA;SERVI, STEFANO;TESSARO, DAVIDE
2009-01-01
Abstract
A new enzymatic synthesis of a,b-dipeptides has been developed with particular focus on the preparation of carnosine (b-alanyl-a-histidine) and analogues. The lipase PS-D from Burkholderia cepacia has been used as a catalyst for the formation of the peptide bond starting from a b-lactam and a protected a-amino acid.File in questo prodotto:
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