Protease catalysed hydrolysis of N-Boc-amino acid esters allows us to obtain N-BOC L-acids and D-esters of amino butanoic acid, nor-leucine, nor-valine, leucine and t-leucine in excellent ee. The reaction occurs in short reaction times and high concentrations. When a biphasic system (buffer-MTBE) is employed, a strong solvent effect is observed. This method could be of significance for the preparation of D-t-leucine, for which a practical method is currently unavailable. (c) 2006 Elsevier Ltd. All rights reserved.
Enzymatic approach to both enantiomers of N-boc hydrophobic amino acids
AGOSTA, ELEONORA CARLA AUGUSTA;CALIGIURI, ANTONIO;D'ARRIGO, PAOLA;SERVI, STEFANO;TESSARO, DAVIDE;
2006-01-01
Abstract
Protease catalysed hydrolysis of N-Boc-amino acid esters allows us to obtain N-BOC L-acids and D-esters of amino butanoic acid, nor-leucine, nor-valine, leucine and t-leucine in excellent ee. The reaction occurs in short reaction times and high concentrations. When a biphasic system (buffer-MTBE) is employed, a strong solvent effect is observed. This method could be of significance for the preparation of D-t-leucine, for which a practical method is currently unavailable. (c) 2006 Elsevier Ltd. All rights reserved.File in questo prodotto:
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