Time-resolved reflectance spectroscopy was used to investigate the effects of photodynamic irradiation on the in vivo absorption properties of disulphonated Aluminum Phthalocyanine (AlS2Pc) in tumor-bearing mice. Mice bearing tumors injected either intramuscularly or intradermally were administered with 5 mg/kg body weight of AlS2Pc. Uptake times of 3 h and 12 h were examined. Absorption spectra were measured from 610 to 700 nm before, during and after the irradiation. The administration of a therapeutic light dose causes a blue-shift and a reduction in the drug absorption, which are more marked 3 h than 12 h after drug injection.
Effects of PDT on the in vito absorption properties of AlS2Pc in tumor-bearing mice
CUBEDDU, RINALDO;D'ANDREA, COSIMO;PIFFERI, ANTONIO GIOVANNI;TARONI, PAOLA;TORRICELLI, ALESSANDRO;VALENTINI, GIANLUCA
2000-01-01
Abstract
Time-resolved reflectance spectroscopy was used to investigate the effects of photodynamic irradiation on the in vivo absorption properties of disulphonated Aluminum Phthalocyanine (AlS2Pc) in tumor-bearing mice. Mice bearing tumors injected either intramuscularly or intradermally were administered with 5 mg/kg body weight of AlS2Pc. Uptake times of 3 h and 12 h were examined. Absorption spectra were measured from 610 to 700 nm before, during and after the irradiation. The administration of a therapeutic light dose causes a blue-shift and a reduction in the drug absorption, which are more marked 3 h than 12 h after drug injection.File in questo prodotto:
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