An imaging system was used to monitor the fluorescence of disulphonated Aluminium Phthalocyanine during the PDT of tumors to check whether an index for therapy effectiveness could be found out. Two excitation wavelengths were tested to discover a possible change in the absorption spectrum of the sensitizer induced by the treatment. Two opposite phenomena take place in the tumor area: a mild photobleaching in the region directly irradiated and a marked increase in the fluorescence signal at the tumor borders. The different behavior observed with the two excitation wavelengths demonstrates that the drug absorption spectrum shifts towards shorter wavelengths as a result of the irradiation.
Fluorescence monitoring during photodynamic therapy of experimental tumors with AlS2Pc
CUBEDDU, RINALDO;D'ANDREA, COSIMO;PIFFERI, ANTONIO GIOVANNI;TARONI, PAOLA;TORRICELLI, ALESSANDRO;VALENTINI, GIANLUCA
2000-01-01
Abstract
An imaging system was used to monitor the fluorescence of disulphonated Aluminium Phthalocyanine during the PDT of tumors to check whether an index for therapy effectiveness could be found out. Two excitation wavelengths were tested to discover a possible change in the absorption spectrum of the sensitizer induced by the treatment. Two opposite phenomena take place in the tumor area: a mild photobleaching in the region directly irradiated and a marked increase in the fluorescence signal at the tumor borders. The different behavior observed with the two excitation wavelengths demonstrates that the drug absorption spectrum shifts towards shorter wavelengths as a result of the irradiation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.