Exploiting compartmentalization to unravel the contribution of cartilage and synovium to osteoarthritis pathogenesis in a novel joint-on-chip platform

The primary barrier in the development of disease-modifying drugs for osteoarthritis (OA) is the limited understanding of the initial pathogenic mechanisms. Here, we developed a compartmentalized joint-on-chip (JoC) model aimed at assessing how the breakdown of the natural communication between cartilage and synovium contributes to OA development.