We present the most compact (4 cm3) time domain diffuse optical spectroscopy system, hosting 8 laser sources emitting at different wavelengths, a large area time-gated detector, and a time-to-digital converter. We tested the optode using standardized protocols, enlightening a high light harvesting capability and large penetration depth in detecting realistic optical inhomogeneities. We tested it also in vivo for the non-invasive assessment of blood parameters in a vascular occlusion test and for the detection of brain activation, demonstrating the optode capability to follow task-related hemodynamic changes even through a single measurement, with no need for averaging or filtering as instead needed with most available systems. The optode is thus a good candidate for next generation home-monitoring devices, thanks to its good performances, small dimension and potential low-cost.

Smart Optode for 8-Wavelength Time-Gated Diffuse Optics

Sieno, Laura Di;Maffeis, Giulia;Mora, Alberto Dalla;Ferocino, Edoardo;Tosi, Alberto;Conca, Enrico;Pifferi, Antonio;Taroni, Paola
2024-01-01

Abstract

We present the most compact (4 cm3) time domain diffuse optical spectroscopy system, hosting 8 laser sources emitting at different wavelengths, a large area time-gated detector, and a time-to-digital converter. We tested the optode using standardized protocols, enlightening a high light harvesting capability and large penetration depth in detecting realistic optical inhomogeneities. We tested it also in vivo for the non-invasive assessment of blood parameters in a vascular occlusion test and for the detection of brain activation, demonstrating the optode capability to follow task-related hemodynamic changes even through a single measurement, with no need for averaging or filtering as instead needed with most available systems. The optode is thus a good candidate for next generation home-monitoring devices, thanks to its good performances, small dimension and potential low-cost.
2024
sezele, SPAD
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1260745
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