We address the problem of controlling the dilution rate in a chemostat to regulate the ratio between the concentrations of two microbial populations growing in continuous culture. After analyzing the open-loop dynamics of this multicellular system, we present two alternative feedback control strategies, one based on a gain-scheduled state feedback controller, the other on a switching control strategy. We show that both strategies are effective in solving the problem and illustrate the results by a set of representative in-silico experiments.

Feedback Ratiometric Control of Two Microbial Populations in a Single Chemostat

Della Rossa F.;
2022-01-01

Abstract

We address the problem of controlling the dilution rate in a chemostat to regulate the ratio between the concentrations of two microbial populations growing in continuous culture. After analyzing the open-loop dynamics of this multicellular system, we present two alternative feedback control strategies, one based on a gain-scheduled state feedback controller, the other on a switching control strategy. We show that both strategies are effective in solving the problem and illustrate the results by a set of representative in-silico experiments.
2022
process control
Systems biology
variable-structure/sliding-mode control
File in questo prodotto:
File Dimensione Formato  
2021 - Feedback_Ratiometric_Control_of_Two_Microbial_Populations_in_a_Single_Chemostat.pdf

Accesso riservato

: Publisher’s version
Dimensione 830.44 kB
Formato Adobe PDF
830.44 kB Adobe PDF   Visualizza/Apri
11311-1186935_Della Rosa.pdf

accesso aperto

: Pre-Print (o Pre-Refereeing)
Dimensione 2.38 MB
Formato Adobe PDF
2.38 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1186935
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
social impact