Glycans are involved in fundamental aspects of cell and organismal biology, such as the receptor-mediated cell to cell interactions that underline both normal and pathological processes. Glycosylation has three broad functions. First, some glycans form structures with unique physical properties. Second, glycans can regulate the function or properties of the entity to which they are attached, for instance by controlling protein stability or receptor dimerization. Last, certain glycans are themselves ligands for lectins, which are carbohydrate-specific receptors. NanoMug can act as glycomimetic drugs with different action sites and pharmaceutical activities: •Antibacterial: interference with the bacterial biofilm formation3. •Antiviral: interference with the virus-cell binding process. •Antitumoral: targeting selectins, Siglecs2. mechanisms that fuel resistance and lower the rate of tumor recurrence.

NanoMuG: a novel protein based drug delivery system

G. Guagliano;P. Petrini;
2021-01-01

Abstract

Glycans are involved in fundamental aspects of cell and organismal biology, such as the receptor-mediated cell to cell interactions that underline both normal and pathological processes. Glycosylation has three broad functions. First, some glycans form structures with unique physical properties. Second, glycans can regulate the function or properties of the entity to which they are attached, for instance by controlling protein stability or receptor dimerization. Last, certain glycans are themselves ligands for lectins, which are carbohydrate-specific receptors. NanoMug can act as glycomimetic drugs with different action sites and pharmaceutical activities: •Antibacterial: interference with the bacterial biofilm formation3. •Antiviral: interference with the virus-cell binding process. •Antitumoral: targeting selectins, Siglecs2. mechanisms that fuel resistance and lower the rate of tumor recurrence.
Mucus, nanoparticles, drug delivery
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1183090
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