It is described an opto-magnetic device sensible to the presence of an analyte in a sample, comprising: an integrated optical circuit (101) having an input (IN) for an input optical radiation and at least one output (OU) for an output optical radiation; said optical circuit defining an area (102) sensible to the variations of a local refraction index probed by the optical radiation, destined to come in contact with the sample; a plurality of probe molecules (105) such to anchor to at least said sensible area (102); a plurality of magnetic particles (107) such to anchor to molecules (106) of the analyte, bound to the probe molecules (105) upon a molecular recognition; a magnetic actuator (108) configured to generate a variable magnetic field and move in an oscillating way said magnetic particles (107) in order to cause a variation of the refraction index probed by the optical radiation in the sensible area (102) of the optical circuit (101), and a variation of at least one characteristic parameter of the output optical radiation correlated to a concentration of the molecules (106) of the analyte in the sample.

OPTO-MAGNETIC SENSOR DEVICE AND MOLECULAR RECOGNITION SYSTEM

Riccardo Bertacco;Andrea Melloni;Nicola Peserico;Parikshit Pratim Sharma
2018

Abstract

It is described an opto-magnetic device sensible to the presence of an analyte in a sample, comprising: an integrated optical circuit (101) having an input (IN) for an input optical radiation and at least one output (OU) for an output optical radiation; said optical circuit defining an area (102) sensible to the variations of a local refraction index probed by the optical radiation, destined to come in contact with the sample; a plurality of probe molecules (105) such to anchor to at least said sensible area (102); a plurality of magnetic particles (107) such to anchor to molecules (106) of the analyte, bound to the probe molecules (105) upon a molecular recognition; a magnetic actuator (108) configured to generate a variable magnetic field and move in an oscillating way said magnetic particles (107) in order to cause a variation of the refraction index probed by the optical radiation in the sensible area (102) of the optical circuit (101), and a variation of at least one characteristic parameter of the output optical radiation correlated to a concentration of the molecules (106) of the analyte in the sample.
Optical biosensor; magnetic nanoparticles; lab on chip
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/1126863
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