In vitro cell/tissue culture represents a widespread methodology to investigate pathophysiology with good cost/benefit ratio, in compliance with the 3R principles. Cell differentiation, co-culture, conditioning under perfusion and recover/reuse are among the key limitations of cell culture, and currently available systems are unsuitable to perform all of them. We developed and are now validating a novel system, allowing compartmentalized cultures, visualization in real time of the culture growth, and recover and reuse of the biological material for subsequent analysis.
IN VITRO VALIDATION OF A NOVEL BICOMPARTMENTAL CULTURE SYSTEM.
L. P. Coppadoro;G. B. Fiore;M. Soncini;
2019-01-01
Abstract
In vitro cell/tissue culture represents a widespread methodology to investigate pathophysiology with good cost/benefit ratio, in compliance with the 3R principles. Cell differentiation, co-culture, conditioning under perfusion and recover/reuse are among the key limitations of cell culture, and currently available systems are unsuitable to perform all of them. We developed and are now validating a novel system, allowing compartmentalized cultures, visualization in real time of the culture growth, and recover and reuse of the biological material for subsequent analysis.File in questo prodotto:
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