Osteoarthritis (OA) is the musculoskeletal disease with the highest prevalence, however, no effective treatment is currently available. OA is recognized as a whole joint disorder, characterized by pathological responses to environmental factors, being mechanical overload and oxidative stress the most relevant. (1) Repeated failures in translating promising disease-modifying OA drugs into clinical success highlight the requirement for more effective disease modeling tools. Organs-on-chip are micro-fabricated devices that, integrating cellular 3D architecture and specific chemo-mechanical in vivo-like milieu, allow recapitulation of organ functions with unprecedented precision. In this study, we developed healthy and OA-like cartilage models through a microbioreactor providing 3D micro-constructs with confined compression representative of either physiological (10%) or hyperphysiological (30%) strains.

Cartilage on chip: Hyper-Physiological Compression in a microscale platform triggers osteoarthritic traits in a cartilage model

Andrea Mainardi;Paola Occhetta;Emiliano Votta;Marco Rasponi
2018

Abstract

Osteoarthritis (OA) is the musculoskeletal disease with the highest prevalence, however, no effective treatment is currently available. OA is recognized as a whole joint disorder, characterized by pathological responses to environmental factors, being mechanical overload and oxidative stress the most relevant. (1) Repeated failures in translating promising disease-modifying OA drugs into clinical success highlight the requirement for more effective disease modeling tools. Organs-on-chip are micro-fabricated devices that, integrating cellular 3D architecture and specific chemo-mechanical in vivo-like milieu, allow recapitulation of organ functions with unprecedented precision. In this study, we developed healthy and OA-like cartilage models through a microbioreactor providing 3D micro-constructs with confined compression representative of either physiological (10%) or hyperphysiological (30%) strains.
Cartilage, Osteochondral, Microfluidics, mechanics
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/1121345
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