Time Domain Diffuse Optical Tomography (TD-DOT) performed at multiple wavelengths can be used to non-invasively probe tissue composition. Then, tissue composition can be related to breast tissue and lesion type. Thus, TD-DOT could be used for therapy monitoring for breast cancer. We developed a software tool for multi-wavelength TD-DOT and performed a validation on meat phantoms to mimic tissue heterogeneity. An inclusion of different meat was exploited to mimic the presence of a lesion in the breast. Results show good localization of the inclusion, but poor quantification of the reconstructed breast composition. The use of a morphological prior constraint, providing information on inclusion geometry and position, significantly improves both localization and composition estimate.

Spectral approach to time domain diffuse optical tomography for breast cancer: validation on meat phantoms

Ferocino, Edoardo;Di Sieno, Laura;Dalla Mora, Alberto;Pifferi, Antonio;Taroni, Paola;Farina, Andrea
2019-01-01

Abstract

Time Domain Diffuse Optical Tomography (TD-DOT) performed at multiple wavelengths can be used to non-invasively probe tissue composition. Then, tissue composition can be related to breast tissue and lesion type. Thus, TD-DOT could be used for therapy monitoring for breast cancer. We developed a software tool for multi-wavelength TD-DOT and performed a validation on meat phantoms to mimic tissue heterogeneity. An inclusion of different meat was exploited to mimic the presence of a lesion in the breast. Results show good localization of the inclusion, but poor quantification of the reconstructed breast composition. The use of a morphological prior constraint, providing information on inclusion geometry and position, significantly improves both localization and composition estimate.
Diffuse Optical Spectroscopy and Imaging VII
9781510628410
9781510628427
Diffuse Optical Tomography, Time Domain, Reflectance, Breast cancer
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1115369
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