Herein we report a halogen bond-donor amino acid, 4-iodotetrafluorophenylalanine, which behaves as a catalyst for the aqueous synthesis of bis-(heterocyclic)methanes. We also provide experimental evidence that halogen bonding is a plausible explanation for the observed catalytic effect.
A halogen bond-donor amino acid for organocatalysis in water
BERGAMASCHI, GRETA;Lascialfari L.;Pizzi A.;Martinez Espinoza M. I.;Milani A.;Metrangolo P.
2018-01-01
Abstract
Herein we report a halogen bond-donor amino acid, 4-iodotetrafluorophenylalanine, which behaves as a catalyst for the aqueous synthesis of bis-(heterocyclic)methanes. We also provide experimental evidence that halogen bonding is a plausible explanation for the observed catalytic effect.File in questo prodotto:
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