Reduction in scattering, high absorption, and spectral features of tissue constituents above 1000 nm could help in gaining higher spatial resolution, penetration depth, and specificity for in vivo studies, opening possibilities of near-infrared diffuse optics in tissue diagnosis. We present the characterization of collagen absorption over a broadband range (500 to 1700 nm) and compare it with spectra presented in the literature. Measurements were performed using a time-domain diffuse optical technique. The spectrum was extracted by carefully accounting for various spectral distortion effects, due to sample and system properties. The contribution of several tissue constituents (water, lipid, collagen, oxy, and deoxy-hemoglobin) to the absorption properties of a collagen-rich in vivo bone location, such as radius distal in the 500-to 1700-nm wavelength region, is also discussed, suggesting bone diagnostics as a potential area of interest.

Diffuse optical characterization of collagen absorption from 500 to 1700 nm

KONUGOLU VENKATA SEKAR, SANATHANA;BARGIGIA, ILARIA;Dalla Mora, Alberto;TARONI, PAOLA;RUGGERI, ALESSANDRO;TOSI, ALBERTO;PIFFERI, ANTONIO GIOVANNI;FARINA, ANDREA
2017

Abstract

Reduction in scattering, high absorption, and spectral features of tissue constituents above 1000 nm could help in gaining higher spatial resolution, penetration depth, and specificity for in vivo studies, opening possibilities of near-infrared diffuse optics in tissue diagnosis. We present the characterization of collagen absorption over a broadband range (500 to 1700 nm) and compare it with spectra presented in the literature. Measurements were performed using a time-domain diffuse optical technique. The spectrum was extracted by carefully accounting for various spectral distortion effects, due to sample and system properties. The contribution of several tissue constituents (water, lipid, collagen, oxy, and deoxy-hemoglobin) to the absorption properties of a collagen-rich in vivo bone location, such as radius distal in the 500-to 1700-nm wavelength region, is also discussed, suggesting bone diagnostics as a potential area of interest.
biomedical optics; collagen absorption; diffuse optics; scattering; time-resolved spectroscopy; Electronic, Optical and Magnetic Materials; Atomic and Molecular Physics, and Optics; Biomaterials; Biomedical Engineering
sezele
File in questo prodotto:
File Dimensione Formato  
Sekar et al._2017.pdf

accesso aperto

Descrizione: pdf-editoriale
: Publisher’s version
Dimensione 1.07 MB
Formato Adobe PDF
1.07 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/1012492
Citazioni
  • ???jsp.display-item.citation.pmc??? 28
  • Scopus 65
  • ???jsp.display-item.citation.isi??? 58
social impact