A retrospective pilot clinical study on time domain multi-wavelength (635 to 1060 nm) optical mammography was exploited to assess collagen as a breast-cancer risk factor on a total of 109 subjects (53 healthy and 56 with malignant lesions). An increased cancer occurrence is observed on the 15% subset of patients with higher age-matched collagen content. Further, a similar clustering based on the percentage breast density leads to a different set of patients, possibly indicating collagen as a new independent breast cancer risk factor. If confirmed statistically and on larger numbers, these results could have huge impact on personalized diagnostics, health care systems, as well as on basic research.

Collagen content as a risk factor in breast cancer? A pilot clinical study

PIFFERI, ANTONIO GIOVANNI;QUARTO, GIOVANNA;CUBEDDU, RINALDO;TARONI, PAOLA
2015-01-01

Abstract

A retrospective pilot clinical study on time domain multi-wavelength (635 to 1060 nm) optical mammography was exploited to assess collagen as a breast-cancer risk factor on a total of 109 subjects (53 healthy and 56 with malignant lesions). An increased cancer occurrence is observed on the 15% subset of patients with higher age-matched collagen content. Further, a similar clustering based on the percentage breast density leads to a different set of patients, possibly indicating collagen as a new independent breast cancer risk factor. If confirmed statistically and on larger numbers, these results could have huge impact on personalized diagnostics, health care systems, as well as on basic research.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
9781628417036
9781628417036
breast cancer; collagen; risk assessment; time-resolved diffuse optical imaging; Tissue diagnostics; Atomic and Molecular Physics, and Optics; Electronic, Optical and Magnetic Materials; Biomaterials; Radiology, Nuclear Medicine and Imaging
File in questo prodotto:
File Dimensione Formato  
ECBO2015_Risk.pdf

accesso aperto

Descrizione: Documento principale
: Post-Print (DRAFT o Author’s Accepted Manuscript-AAM)
Dimensione 258.11 kB
Formato Adobe PDF
258.11 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/983542
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact