The present work focuses on the main parameters that influence shear-promoted encapsulation of drugs into erythrocytes. A CFD model was built to investigate the fluid dynamics of a suspension of particles flowing in a commercial micro channel. Micro Particle Image Velocimetry (μ-PIV) allowed to take into account for the real properties of the red blood cell (RBC), thus having a deeper understanding of the process. Coupling these results with an analytical diffusion model, suitable working conditions were defined for different values of haematocrit.
Shear-promoted drug encapsulation into red blood cells: a CFD model and μ-PIV analysis
PIERGIOVANNI, MONICA;CASAGRANDE, GIUSTINA;BIANCHI, ELENA;COSTANTINO, MARIA LAURA
2015-01-01
Abstract
The present work focuses on the main parameters that influence shear-promoted encapsulation of drugs into erythrocytes. A CFD model was built to investigate the fluid dynamics of a suspension of particles flowing in a commercial micro channel. Micro Particle Image Velocimetry (μ-PIV) allowed to take into account for the real properties of the red blood cell (RBC), thus having a deeper understanding of the process. Coupling these results with an analytical diffusion model, suitable working conditions were defined for different values of haematocrit.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
ESB-ITA-2015.pdf
Accesso riservato
Dimensione
7.58 MB
Formato
Adobe PDF
|
7.58 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
