In-vitro tests and analyses are of fundamental importance for investigating biological mechanisms in cells and bio-molecules. The controlled application of forces to activate specific bio-pathways and investigate their effects, mimicking the role of the cellular environment, is becoming a prominent approach in this field. In this work, we present a non-invasive magnetic on-chip platform which allows for the manipulation of magnetic particles, through micrometric magnetic conduits of Permalloy patterned on-chip. We show, from simulations and experiments, that this technology permits to exert a finely controlled force on magnetic beads along the chip surface. This force can be tuned from few to hundreds pN by applying a variable external magnetic field.

Towards an on-chip platform for the controlled application of forces via magnetic particles: A novel device for mechanobiology

MONTICELLI, MARCO;ALBISETTI, EDOARDO;PETTI, DANIELA;CONCA, DARIO VALTER;FALCONE, MATTEO;SHARMA, PARIKSHIT PRATIM;BERTACCO, RICCARDO
2015

Abstract

In-vitro tests and analyses are of fundamental importance for investigating biological mechanisms in cells and bio-molecules. The controlled application of forces to activate specific bio-pathways and investigate their effects, mimicking the role of the cellular environment, is becoming a prominent approach in this field. In this work, we present a non-invasive magnetic on-chip platform which allows for the manipulation of magnetic particles, through micrometric magnetic conduits of Permalloy patterned on-chip. We show, from simulations and experiments, that this technology permits to exert a finely controlled force on magnetic beads along the chip surface. This force can be tuned from few to hundreds pN by applying a variable external magnetic field.
Magnetic particles, mechanobiology
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/970968
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