The most odorous stereoisomers of the chiral com. fragrance Muguesia are prepd. by a very effective linear biocatalyzed cascade reaction, in which a suitable unsatd. ketone is submitted to the sequential action of two enzymes, an enereductase and an alc. dehydrogenase, which are added together to the same reaction vessel with the cofactor regeneration system. Two stereogenic centers in 1,2 relative position are thus created under high stereochem. control by a two-step one-pot enzymic procedure.
Multi-enzyme cascade synthesis of the most odorous stereoisomers of the commercial odorant Muguesia
BRENNA, MARIA ELISABETTA;CROTTI, MICHELE;GATTI, FRANCESCO GILBERTO;PARMEGGIANI, FABIO;SANTANGELO, SARA
2015-01-01
Abstract
The most odorous stereoisomers of the chiral com. fragrance Muguesia are prepd. by a very effective linear biocatalyzed cascade reaction, in which a suitable unsatd. ketone is submitted to the sequential action of two enzymes, an enereductase and an alc. dehydrogenase, which are added together to the same reaction vessel with the cofactor regeneration system. Two stereogenic centers in 1,2 relative position are thus created under high stereochem. control by a two-step one-pot enzymic procedure.File in questo prodotto:
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