In the early phase of the clinical experience with the Alfieri technique, we were confronted with several unanswered questions in search for an urgent answer. While the technique seemed to be reliable and easy to apply in different settings, the clinical and pathophysiological consequences of creating a double-orifice valve were unknown. The main questions were concerning the hemodynamics of a double-orifice valve: How much the double-orifice configuration affects diastolic transmitral flow? How is the transmitral flow after a symmetric vs. asymmetric double-orifice repair? Are Doppler derived hemodynamics a reliable method to assess transmitral flow dynamics? What is the risk of leaflet tear? What is the risk of generating mitral stenosis when a ring is added to the Alfieri technique? Is turbulent flow associated with higher risk of thromboembolism?
The Principle: From a Computational Model to Clinical Validation
STURLA, FRANCESCO;VOTTA, EMILIANO;REDAELLI, ALBERTO CESARE LUIGI;
2015-01-01
Abstract
In the early phase of the clinical experience with the Alfieri technique, we were confronted with several unanswered questions in search for an urgent answer. While the technique seemed to be reliable and easy to apply in different settings, the clinical and pathophysiological consequences of creating a double-orifice valve were unknown. The main questions were concerning the hemodynamics of a double-orifice valve: How much the double-orifice configuration affects diastolic transmitral flow? How is the transmitral flow after a symmetric vs. asymmetric double-orifice repair? Are Doppler derived hemodynamics a reliable method to assess transmitral flow dynamics? What is the risk of leaflet tear? What is the risk of generating mitral stenosis when a ring is added to the Alfieri technique? Is turbulent flow associated with higher risk of thromboembolism?I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
