19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods.
A Superfluorinated Molecular Probe for Highly Sensitivein Vivo19F-MRI
TIROTTA, ILARIA;GAZZERA, LARA;BASELLI, GIUSEPPE;CAVALLO, GABRIELLA;TERRANEO, GIANCARLO;BALDELLI BOMBELLI, FRANCESCA;METRANGOLO, PIERANGELO;RESNATI, GIUSEPPE
2014-01-01
Abstract
19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods.File in questo prodotto:
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A Superfluorinated Molecular Probe for Highly Sensitive in Vivo(19)F-MRI.pdf
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A Superfluorinated Molecular Probe_11311-844588_Metrangolo.pdf
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