The mechanisms and the causes of the in-stent restenosis process in coronary arteries are not fully understood. One of the most relevant phenomena, which seems to be associated to this process, is an altered hemodynamics in the stented wall region. In vivo local measurements of velocities and their gradients in human coronary arteries are very difficult and can hardly be applied to successfully investigate the fluid dynamic field. Alternatively, virtual models of blood flow in patient-specific coronary arteries allow the study of local fluid dynamics and the computation of the wall shear stress (WSS) and other quantities which can be related to the risk of restenosis. Currently, the majority of the numerical studies consider idealized geometries, lacking of patient-specificity. The aim of the present work is to investigate the fluid dynamics in patient-specific stented coronary artery models which replicate the complete clinical procedure of stenting implantation, with particular emphasis on how local hemodynamic structures might influence flow-mediated processes leading to restenosis.

Patient-specific stented coronary bifurcations: numerical analysis of near-wall quantities and bulk flow

CHIASTRA, CLAUDIO;DUBINI, GABRIELE ANGELO;MIGLIAVACCA, FRANCESCO
2013-01-01

Abstract

The mechanisms and the causes of the in-stent restenosis process in coronary arteries are not fully understood. One of the most relevant phenomena, which seems to be associated to this process, is an altered hemodynamics in the stented wall region. In vivo local measurements of velocities and their gradients in human coronary arteries are very difficult and can hardly be applied to successfully investigate the fluid dynamic field. Alternatively, virtual models of blood flow in patient-specific coronary arteries allow the study of local fluid dynamics and the computation of the wall shear stress (WSS) and other quantities which can be related to the risk of restenosis. Currently, the majority of the numerical studies consider idealized geometries, lacking of patient-specificity. The aim of the present work is to investigate the fluid dynamics in patient-specific stented coronary artery models which replicate the complete clinical procedure of stenting implantation, with particular emphasis on how local hemodynamic structures might influence flow-mediated processes leading to restenosis.
2013
ASME 2013 Summer Bioengineering Conference, SBC 2013
9780791855607
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/762329
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