The development of complex and vascularized tissue engineered models requires the ability to geometrically tailor in vitro the ECM microarchitecture found in vivo. In this study, a mold patterning protocol to obtain cell laden photocrosslinkable hydrogel micropatterns with highly controlled geometrical features is thus presented. Analysis on spatial fidelity and a preliminary biological validation demonstrated this protocol allows forming 3D homogeneous micropatterns with a high fidelity and user- defined size and shape, using a low-cost UVB source.

Control the geometry of photopolymerizable hydrogels through a microscaled mold patterning protocol

OCCHETTA, PAOLA;PIRAINO, FRANCESCO;REDAELLI, ALBERTO CESARE LUIGI;RASPONI, MARCO
2012

Abstract

The development of complex and vascularized tissue engineered models requires the ability to geometrically tailor in vitro the ECM microarchitecture found in vivo. In this study, a mold patterning protocol to obtain cell laden photocrosslinkable hydrogel micropatterns with highly controlled geometrical features is thus presented. Analysis on spatial fidelity and a preliminary biological validation demonstrated this protocol allows forming 3D homogeneous micropatterns with a high fidelity and user- defined size and shape, using a low-cost UVB source.
Congresso Nazionale di Bioingegneria 2012 Atti
9788855531825
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/665728
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