The development of complex and vascularized tissue engineered models requires the ability to geometrically tailor in vitro the ECM microarchitecture found in vivo. In this study, a mold patterning protocol to obtain cell laden photocrosslinkable hydrogel micropatterns with highly controlled geometrical features is thus presented. Analysis on spatial fidelity and a preliminary biological validation demonstrated this protocol allows forming 3D homogeneous micropatterns with a high fidelity and user- defined size and shape, using a low-cost UVB source.
Control the geometry of photopolymerizable hydrogels through a microscaled mold patterning protocol
OCCHETTA, PAOLA;PIRAINO, FRANCESCO;REDAELLI, ALBERTO CESARE LUIGI;RASPONI, MARCO
2012-01-01
Abstract
The development of complex and vascularized tissue engineered models requires the ability to geometrically tailor in vitro the ECM microarchitecture found in vivo. In this study, a mold patterning protocol to obtain cell laden photocrosslinkable hydrogel micropatterns with highly controlled geometrical features is thus presented. Analysis on spatial fidelity and a preliminary biological validation demonstrated this protocol allows forming 3D homogeneous micropatterns with a high fidelity and user- defined size and shape, using a low-cost UVB source.File in questo prodotto:
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