The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two gamma-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.
MULTISTEP PROCESS FOR THE PHYSICAL DEPOLYMERIZATION OF HEPARIN AND PRODUCTS OBTAINED THEREFROM
VISMARA, ELENA
2005-01-01
Abstract
The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two gamma-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.File in questo prodotto:
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