Lewis acids catalyze the condensation of (-)-MeCOCO2R (R = menthyl) and 1-naphthol to give 60-98% menthyl naphthaleneacetate I in a ratio of up to 96:4 in favor of the levorotatory diastereoisomer. Epimerization at 25° for 5 days occurs on benzylic C to give a 30:70 mixt. enriched with the dextrorotatory isomer
Asymmetric aldol condensation of 1-naphthol and pyruvates in the presence of Lewis acids
CITTERIO, ATTILIO
1984-01-01
Abstract
Lewis acids catalyze the condensation of (-)-MeCOCO2R (R = menthyl) and 1-naphthol to give 60-98% menthyl naphthaleneacetate I in a ratio of up to 96:4 in favor of the levorotatory diastereoisomer. Epimerization at 25° for 5 days occurs on benzylic C to give a 30:70 mixt. enriched with the dextrorotatory isomerFile in questo prodotto:
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