Like most biologically active compounds, chiral fragrances have different flavour response in the two enantiomeric forms. This is the case of the norterpenoids alpha-ionone and alpha-damascone. In this work we present the resolution of racemic alpha-ionone and alpha-damascone through a special chromatographic technique, the Simulated Moving Bed, which allows to feed continuously the mixture to be separated. This process was originally developed for hydrocarbon separations and is now being applied in fine chemistry to the separation of enantiomers since, unlike the traditional preparative chromatography, it does not require baseline separation. In addition, it leads to higher productivity and lower eluent consumption.
Preparative separation of alpha-ionone and alpha-damascone enantiomers with simulated moving bed chromatography
MAZZOTTI, MARCO GIUSEPPE;MORBIDELLI, MASSIMO
2001-01-01
Abstract
Like most biologically active compounds, chiral fragrances have different flavour response in the two enantiomeric forms. This is the case of the norterpenoids alpha-ionone and alpha-damascone. In this work we present the resolution of racemic alpha-ionone and alpha-damascone through a special chromatographic technique, the Simulated Moving Bed, which allows to feed continuously the mixture to be separated. This process was originally developed for hydrocarbon separations and is now being applied in fine chemistry to the separation of enantiomers since, unlike the traditional preparative chromatography, it does not require baseline separation. In addition, it leads to higher productivity and lower eluent consumption.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
