In this work, the first enantioseparation in a SF-SMB unit, i.e., a simulated moving bed (SMB) operated under supercritical conditions, is reported. Complete separation of the two enantiomers of tetralol was achieved both in the pressure-gradient mode (where a pressure gradient is imposed along the four sections of the unit) and in the isocratic mode (where the pressure is kept constant). However, an almost 3-fold increase in productivity could be achieved in the pressure-gradient rather than the isocratic mode. The obtained results are explained and rationalized using recently developed design criteria for SMBs, the so-called "triangle theory", which have been properly extended to allow for different pressure values in the different sections of the unit.

Enantioseparation through supercritical fluid simulated moving bed (SF-SMB) chromatography

MAZZOTTI, MARCO GIUSEPPE;MORBIDELLI, MASSIMO
2001

Abstract

In this work, the first enantioseparation in a SF-SMB unit, i.e., a simulated moving bed (SMB) operated under supercritical conditions, is reported. Complete separation of the two enantiomers of tetralol was achieved both in the pressure-gradient mode (where a pressure gradient is imposed along the four sections of the unit) and in the isocratic mode (where the pressure is kept constant). However, an almost 3-fold increase in productivity could be achieved in the pressure-gradient rather than the isocratic mode. The obtained results are explained and rationalized using recently developed design criteria for SMBs, the so-called "triangle theory", which have been properly extended to allow for different pressure values in the different sections of the unit.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/659002
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