The mass spectrometric behaviour of barbituric acid and 1,3-dimethylbarbituric acid was compared with that of the corresponding 5,5-difluoro derivatives and of some 5-fluoro-5-alkyl derivatives in order to study the influence of fluorine in the fragmentation processes. This investigation, performed using both electron impact ionization and positive- and negative-ion fast atom bombardment, evidences well the role of fluorine in barbiturate ring bond cleavages.
Comparison by mass spectrometry of ring cleavage in barbituric acid and 5-fluorobarbituric acid derivatives
RESNATI, GIUSEPPE;
1992-01-01
Abstract
The mass spectrometric behaviour of barbituric acid and 1,3-dimethylbarbituric acid was compared with that of the corresponding 5,5-difluoro derivatives and of some 5-fluoro-5-alkyl derivatives in order to study the influence of fluorine in the fragmentation processes. This investigation, performed using both electron impact ionization and positive- and negative-ion fast atom bombardment, evidences well the role of fluorine in barbiturate ring bond cleavages.File in questo prodotto:
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