The title iodinane 3 (Umemoto's FMITS-1) is prepared in two steps from the readily accessible CF3CH2ICl2 (1). 1 and 2 eq. of CF3COOAg react in CFCl2CF2Cl (FC 113) to give CF3CH2(OCOCF3)2 (2) which is converted into 3 by the known method. With this modification, chlorine and nontoxic FC 113 replace 60–80% H2O2 and trifluoroacetic anhydride as the oxidant and the solvent, respectively, in the synthesis of the intermediate 2. The N-trifluoroethylation of some aminoalcohols by FMITS-1 is also reported.
Trifluoroethyl phenyl iodonium triflate: Modified preparation and N-trifluoroethylation of amino alcohols
RESNATI, GIUSEPPE
1994-01-01
Abstract
The title iodinane 3 (Umemoto's FMITS-1) is prepared in two steps from the readily accessible CF3CH2ICl2 (1). 1 and 2 eq. of CF3COOAg react in CFCl2CF2Cl (FC 113) to give CF3CH2(OCOCF3)2 (2) which is converted into 3 by the known method. With this modification, chlorine and nontoxic FC 113 replace 60–80% H2O2 and trifluoroacetic anhydride as the oxidant and the solvent, respectively, in the synthesis of the intermediate 2. The N-trifluoroethylation of some aminoalcohols by FMITS-1 is also reported.File in questo prodotto:
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