The assessment of the suitability of the biomechanical performances of a medical device intended to replace either a function or tissue, is a primary issue in the pre-clinical evaluation of a new device. Such evaluation is usually performed by means of either experimental facilities or computational simulation or, better, by the interaction of both the methodologies. Difficulties arise when trying to combine the need of simulating the complexity of the biological response to the implant with the necessity of maintaining a reproducible and simple experimental procedure. At LaBS, devices for the treatment of pathologies of lower limbs and spine are subjected to purposely designed experimental protocols and numerical simulations in order to take into account requests regarding their anatomical, functional and surgical compatibility, as well as their mechanical reliability in time. Two examples of such preclinical studies are here given: in particular the impact of different surgical techniques used in the implant of an interspinous device on its functional compatibility has been investigated by means of an experimental animal model; the fatigue resistances of the tibial tray of a polymethyl methacrylate (PMMA) knee spacer have been predicted and validated by means of a combined computational and experimental procedure, using advanced stress criterion based on stress invariants
Pre-clinical Evaluation of the Biomechanical Behavior of ImplantableDevices for Orthopedic and Spinal Surgery
VILLA, TOMASO MARIA TOBIA;GASTALDI, DARIO;PENNATI, GIANCARLO
2010-01-01
Abstract
The assessment of the suitability of the biomechanical performances of a medical device intended to replace either a function or tissue, is a primary issue in the pre-clinical evaluation of a new device. Such evaluation is usually performed by means of either experimental facilities or computational simulation or, better, by the interaction of both the methodologies. Difficulties arise when trying to combine the need of simulating the complexity of the biological response to the implant with the necessity of maintaining a reproducible and simple experimental procedure. At LaBS, devices for the treatment of pathologies of lower limbs and spine are subjected to purposely designed experimental protocols and numerical simulations in order to take into account requests regarding their anatomical, functional and surgical compatibility, as well as their mechanical reliability in time. Two examples of such preclinical studies are here given: in particular the impact of different surgical techniques used in the implant of an interspinous device on its functional compatibility has been investigated by means of an experimental animal model; the fatigue resistances of the tibial tray of a polymethyl methacrylate (PMMA) knee spacer have been predicted and validated by means of a combined computational and experimental procedure, using advanced stress criterion based on stress invariantsFile | Dimensione | Formato | |
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