The goal of the present work was to develop a framework for the quantitative analysis of time-varying MV geometry from cardiac magnetic resonance (CMR) imaging, and to integrate these data in a patient-specific structural simulation of MV closure. CMR imaging of 18 long-axis planes was performed on a healthy subject with a temporal resolution of 55 time-frames per cardiac cycle. Three-dimensional MV annulus geometry, leaflets surface and PMs position were manually obtained using custom software. Hyperelastic anisotropic mechanical properties were assigned to the MV tissues, and a physiological pressure load curve was applied to the leaflets. Preliminary results concerning different aspects of MV biomechanics, such as valve dynamics, leaflets coaptation, leaflets strains and chordae tendineae tensions, were in good agreement with in vitro observations and previous FEMs outcomes. In this study, we demonstrated the feasibility of a MV model based on patient-specific data obtained from CMR. This approach could overcome the limitations of previously proposed models and give new insight into the complex MV function. These models could constitute the basis for accurate evaluation of MV pathologic conditions and for the planning of surgical procedures.
Feasibility of Patient-Specific Finite Element Modeling of the Mitral Valve from Cardiac MRI
STEVANELLA, MARCO;MAFFESSANTI, FRANCESCO;ARNOLDI, ALICE;VOTTA, EMILIANO;CAIANI, ENRICO GIANLUCA;REDAELLI, ALBERTO CESARE LUIGI
2010-01-01
Abstract
The goal of the present work was to develop a framework for the quantitative analysis of time-varying MV geometry from cardiac magnetic resonance (CMR) imaging, and to integrate these data in a patient-specific structural simulation of MV closure. CMR imaging of 18 long-axis planes was performed on a healthy subject with a temporal resolution of 55 time-frames per cardiac cycle. Three-dimensional MV annulus geometry, leaflets surface and PMs position were manually obtained using custom software. Hyperelastic anisotropic mechanical properties were assigned to the MV tissues, and a physiological pressure load curve was applied to the leaflets. Preliminary results concerning different aspects of MV biomechanics, such as valve dynamics, leaflets coaptation, leaflets strains and chordae tendineae tensions, were in good agreement with in vitro observations and previous FEMs outcomes. In this study, we demonstrated the feasibility of a MV model based on patient-specific data obtained from CMR. This approach could overcome the limitations of previously proposed models and give new insight into the complex MV function. These models could constitute the basis for accurate evaluation of MV pathologic conditions and for the planning of surgical procedures.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
