A strongly improved, highly stereoselective synthesis of (S)-alpha-trifluoromethyl aspartic acid via a stereocontrolled Mannich-type addition of liyhium malonate to a chiral sulfinimine of trifluoropyruvate is presented. The described synthesis is very efficient and simple, and can be obviously extended to the (R)- enantiomer.
Mannich-type reaction of methylene active compounds with a chiral sulfinimine of trifluoropyruvate: new highly stereoselective synthesis of (S)-alfa-trifluoromethyl-aspartic acid
BRUCHE', LUCA ALFREDO CASIMIRO;
2005-01-01
Abstract
A strongly improved, highly stereoselective synthesis of (S)-alpha-trifluoromethyl aspartic acid via a stereocontrolled Mannich-type addition of liyhium malonate to a chiral sulfinimine of trifluoropyruvate is presented. The described synthesis is very efficient and simple, and can be obviously extended to the (R)- enantiomer.File in questo prodotto:
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