A numerical study for comparing two response-adaptive designs for continuous treatment effects

We study two sequential, response-adaptive randomized designs for clinical trials; one has been proposed in Bandyopadhyay and Biswas (Biometrika 88: 409–419, 2001) and in Biswas and Basu (Sankhya Ser B 63:27–42, 2001), the other stems from the randomly reinforced urn introduced and studied in Muliere et al. (J Stat Plan Inference 136:1853–1874, 2006a). Both designs can be used in clinical trials where the response from each patient is a continuous variable. Comparison is conducted through numerical studies andalong a new guideline for the evaluation of a response-adaptive design.