An amine, an aldehyde, and methanol can be readily assembled in one pot under very mild conditions through a free-radical multicomponent reaction by using an aqueous acidic TiCl3/t-BuOOH system to afford 1,2-amino alcohols in fair to excellent yields.

A New One-Pot, Four-Component Synthesis of 1,2-Amino Alcohols: TiCl3/t-BuOOH-Mediated Radical Hydroxymethylation of Imines

CLERICI, ANGELO;GHILARDI, ALESSANDRA;PASTORI, NADIA;PUNTA, CARLO;PORTA, OMBRETTA
2008

Abstract

An amine, an aldehyde, and methanol can be readily assembled in one pot under very mild conditions through a free-radical multicomponent reaction by using an aqueous acidic TiCl3/t-BuOOH system to afford 1,2-amino alcohols in fair to excellent yields.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/544735
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