An amine, an aldehyde, and methanol can be readily assembled in one pot under very mild conditions through a free-radical multicomponent reaction by using an aqueous acidic TiCl3/t-BuOOH system to afford 1,2-amino alcohols in fair to excellent yields.
A New One-Pot, Four-Component Synthesis of 1,2-Amino Alcohols: TiCl3/t-BuOOH-Mediated Radical Hydroxymethylation of Imines
CLERICI, ANGELO;GHILARDI, ALESSANDRA;PASTORI, NADIA;PUNTA, CARLO;PORTA, OMBRETTA
2008-01-01
Abstract
An amine, an aldehyde, and methanol can be readily assembled in one pot under very mild conditions through a free-radical multicomponent reaction by using an aqueous acidic TiCl3/t-BuOOH system to afford 1,2-amino alcohols in fair to excellent yields.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
2008-OL-idrossimetilazione.pdf
Accesso riservato
:
Altro materiale allegato
Dimensione
88.74 kB
Formato
Adobe PDF
|
88.74 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
