The present invention refers to the use of novel mols. able to bind tenaciously to silica, borosilicate and silicate surfaces, and thus to modify their properties and characteristics. When applied to silica-based chromatog., it offers important advantages in all cases in which it is necessary to modulate the interaction of analytes with the stationary phase. In capillary zone electrophoresis (CZE), such compds. will eliminate or invert the electroendoosmostic (EEO) flow, greatly simplifying the anal. of neg.-charged compds. and permitting the anal. of bio(macro)mols. via the direct use of naked capillaries
New methods for surface modification of silica for use in capillary zone electrophoresis and chromatography
CITTERIO, ATTILIO;SEBASTIANO, ROBERTO;RIGHETTI, PIERGIORGIO
2001-01-01
Abstract
The present invention refers to the use of novel mols. able to bind tenaciously to silica, borosilicate and silicate surfaces, and thus to modify their properties and characteristics. When applied to silica-based chromatog., it offers important advantages in all cases in which it is necessary to modulate the interaction of analytes with the stationary phase. In capillary zone electrophoresis (CZE), such compds. will eliminate or invert the electroendoosmostic (EEO) flow, greatly simplifying the anal. of neg.-charged compds. and permitting the anal. of bio(macro)mols. via the direct use of naked capillariesFile in questo prodotto:
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