A new, highly promising strategy in drug discovery, consisting in the replacement of the natural peptide or amide function by a xenobiotic trifluoroethylamine is discussed. The trifluoroehtylamino function shows as a very promising peptide- and amide-bond isostere that will likely find extensive application in medicinal chemistry and drug discovery.
The trifluoroethylamine function as peptide bond replacement
BRUCHE', LUCA ALFREDO CASIMIRO;SANI, MONICA;SINISI, ROBERTA;JAGODZINSKA, MONIKA;
2006-01-01
Abstract
A new, highly promising strategy in drug discovery, consisting in the replacement of the natural peptide or amide function by a xenobiotic trifluoroethylamine is discussed. The trifluoroehtylamino function shows as a very promising peptide- and amide-bond isostere that will likely find extensive application in medicinal chemistry and drug discovery.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
ChemistryToday.pdf
Accesso riservato
:
Post-Print (DRAFT o Author’s Accepted Manuscript-AAM)
Dimensione
145.49 kB
Formato
Adobe PDF
|
145.49 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
