In the course of our studies, we have disclosed the manifold roles simultaneously played by Ti(III) and Ti(IV) ions in promoting radical Mannich-type MCRs. As a part of our ongoing interest in this area, we now report that the aqueous acidic Ti(III)/H2O2 system readily assembles an amine, an aldehyde, and formamide in a one-pot reaction leading to a wide range of alpha-aminoamides in fair to good yields.
Free radical version of the Strecker synthesis to alfa-aminoamides promoted by aqueous H2O2/TiCl3/HCONH2 system
CANNELLA, ROSALBA;CLERICI, ANGELO;PASTORI, NADIA;PUNTA, CARLO;PORTA, OMBRETTA
2006-01-01
Abstract
In the course of our studies, we have disclosed the manifold roles simultaneously played by Ti(III) and Ti(IV) ions in promoting radical Mannich-type MCRs. As a part of our ongoing interest in this area, we now report that the aqueous acidic Ti(III)/H2O2 system readily assembles an amine, an aldehyde, and formamide in a one-pot reaction leading to a wide range of alpha-aminoamides in fair to good yields.File in questo prodotto:
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2006-JACS-Radical Strecker.pdf
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