Nanoparticelle di poli(3-esiltiofene)ossidato per il trattamento delle malattie degenerative della retina

The present invention is based on the finding that organic thiophene-based core@shell nanoparticles made of poly(3-hexylthiophene) (P3HT) in the core and oxidized poly(3-hexylthiophene) (PTDO) chains in the shell are effective in photostimulation of inner retinal neurons and constitute a promising tool for biomedical applications in the context of neuronal stimulation and neuroprosthesis and, in particular, in the treatment of degenerative retinal diseases. The invention relates to a polymeric nanoparticle having a core@shell structure comprising poly(3-hexylthiophene) in the core and oxidized poly(3-hexylthiophene) (PTDO) (also referred to in the following as in the shell for use as a medicament and, in particular, for use in ameliorating and/or treating neurodegenerative retinal diseases. The present invention also relates to a pharmaceutical formulation comprising the polymeric nanoparticles having a core@shell structure comprising poly(3-hexylthiophene) in the core and oxidized poly(3-hexylthiophene) (PTDO), which is preferably a formulation for the subretinal injection. The present invention further relates to a process for the preparation of polymeric nanoparticle having a core@shell structure comprising poly(3-hexylthiophene) in the core and oxidized poly(3-hexylthiophene) (PTDO) the comprising the post-functionalization of a preformed colloidal suspension of poly(3-hexylthiophene) nanoparticles by the use of Rozen’s reagent. The present invention further relates to a method for the treatment or improvement of degenerative retinal diseases comprising the step of administrating to a patient in need thereof a pharmaceutically effective quantity of polymeric nanoparticles having a core@shell structure comprising polythiophene in the core and oxidized polythiophene in the shell.