Three model hydantoin-based universal peptidomimetics are designed and synthetized. Their preferred amphiphilic -turn conformation was assessed by molecular modeling and NMR experiments, and their antibacterial acivity tasted against Gram positive and Gram negative bacteria strains, demostrating that these compounds could be a captivating class of antibiotic to fight emergent drug resistance
Synthesis of Amphiphilic Hydantoin-based Universal Peptidomimetics as Antibiotic Agents
Volonterio, Alessandro;
2023-01-01
Abstract
Three model hydantoin-based universal peptidomimetics are designed and synthetized. Their preferred amphiphilic -turn conformation was assessed by molecular modeling and NMR experiments, and their antibacterial acivity tasted against Gram positive and Gram negative bacteria strains, demostrating that these compounds could be a captivating class of antibiotic to fight emergent drug resistanceFile in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
D3OB01247F_accepted.pdf
accesso aperto
:
Pre-Print (o Pre-Refereeing)
Dimensione
1.33 MB
Formato
Adobe PDF
|
1.33 MB | Adobe PDF | Visualizza/Apri |
|
Org. Biomol. Chem. 2023, 7702-7706.pdf
accesso aperto
:
Publisher’s version
Dimensione
527.92 kB
Formato
Adobe PDF
|
527.92 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
