Evaluation of neoadjuvant chemotherapy-induced changes in contralateral healthy breast tissue through diffuse optical spectroscopy

This study aims at evaluating the effect of NeoAdjuvant Chemotherapy (NAC) on the contralateral tumor-free breast tissue through time domain diffuse optical spectroscopy. The breast tissue composition consisting of hemoglobin, water, lipid, and collagen concentrations is quantitatively derived using our seven-wavelength (635-1060 nm) optical mammograph. Preliminary analysis of ten patients' data shows compositional changes occurring in the non-tumor breast in addition to the tumor breast. This includes reduction in breast density and components’ concentrations through the course of the therapy. The final goal is to eventually identify if there is a correlation of these effects with pathological complete response.