A Study on the Intersection of Ground Reaction Forces during Overground Walking in Down Syndrome: Effects of the Pathology and Left-Right Asymmetry

Motor dysfunctions in patients with Down Syndrome (DS) result in poor locomotion and an altered gait phenotype, characterized by compromised stability management and frequent bilateral asymmetries. Directing ground reaction forces to a point above the center of mass, referred to as the virtual pivot point (VPP), is one means of maintaining stability during walking. This cross-sectional observational study compared the dynamic gait function of 33 individuals with DS (mean age: 17.7 +/- 6.4 years, 13 females) to a group of 36 healthy controls (mean age: 15.5 +/- 6.1 years, 15 females), using the concept of the VPP. Results showed that the VPP was located more anteriorly in individuals with DS compared to healthy controls, with no differences in the variability (R-2) or symmetry of VPP coordinates. This anterior VPP position is likely due to the larger hip moments observed in patients with DS during the propulsive phase of stance. High R-2 values in DS suggest that the VPP is strongly related to dynamic stability during walking.