In silico trials aim to speed up the introduction of new devices in clinical practice by testing device design and performance in different patient scenarios and improving patient stratification for optimizing clinical trials. In this paper, we demonstrate an in silico trial framework for thrombectomy treatment of acute ischemic stroke and apply this framework to compare treatment outcomes in different subpopulations and with different thrombectomy stent-retriever devices. We employ a novel surrogate thrombectomy model to evaluate the thrombectomy success in the in silico trial.

In silico thrombectomy trials for acute ischemic stroke

Bridio, Sara;Luraghi, Giulia;Rodriguez Matas, Jose F;Migliavacca, Francesco;
2023-01-01

Abstract

In silico trials aim to speed up the introduction of new devices in clinical practice by testing device design and performance in different patient scenarios and improving patient stratification for optimizing clinical trials. In this paper, we demonstrate an in silico trial framework for thrombectomy treatment of acute ischemic stroke and apply this framework to compare treatment outcomes in different subpopulations and with different thrombectomy stent-retriever devices. We employ a novel surrogate thrombectomy model to evaluate the thrombectomy success in the in silico trial.
2023
Acute ischemic stroke
Computational biology
In silico trials
Simulation frameworks
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1227609
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