Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide-SDSYGAP-derived from resilin, a rubber-like protein exerting its role in the jumping and flight systems of insects. Elastic and resilient hydrogels are obtained, which also show self-healing behavior, thanks to the promoted non-covalent interactions that limit deformations and contribute to the structural recovery of the peptide-based hydrogel. In particular, halogen bonds may stabilize the beta-sheet organization working as non-covalent cross-links between nearby peptide strands. Importantly, the unmodified peptide (i.e., wild type) does not show such properties. Thus, SDSY(3,5-Br)GAP is a novel minimalist peptide elastomer.

Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination

Pizzi, Andrea;Sori, Lorenzo;Pigliacelli, Claudia;Gautieri, Alfonso;Bergamaschi, Greta;Gori, Alessandro;Grande, Antonio Mattia;Baldelli Bombelli, Francesca;Soncini, Monica;Metrangolo, Pierangelo
2022

Abstract

Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide-SDSYGAP-derived from resilin, a rubber-like protein exerting its role in the jumping and flight systems of insects. Elastic and resilient hydrogels are obtained, which also show self-healing behavior, thanks to the promoted non-covalent interactions that limit deformations and contribute to the structural recovery of the peptide-based hydrogel. In particular, halogen bonds may stabilize the beta-sheet organization working as non-covalent cross-links between nearby peptide strands. Importantly, the unmodified peptide (i.e., wild type) does not show such properties. Thus, SDSY(3,5-Br)GAP is a novel minimalist peptide elastomer.
bromination
elastomers
halogen bonding
peptides
resilin
self-assembly
supramolecular chemistry
Elasticity
Hydrogels
Insect Proteins
Peptides
Halogenation
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1220511
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