Since the outbreak of the COVID-19 pandemic, many research organizations have studied the genome of the SARS-CoV-2 virus; a body of public resources have been published for monitoring its evolution. While we experience an unprecedented richness of information in this domain, we also ascertained the presence of several information quality issues. We hereby propose CoV2K, an abstract model for explaining SARS-CoV-2-related concepts and interactions, focusing on viral mutations, their co-occurrence within variants, and their effects. CoV2K provides a clear and concise route map for understanding different connected types of information related to the virus; it thus drives a process of data and knowledge integration that aggregates information from several current resources, harmonizing their content and overcoming incompleteness and inconsistency issues. CoV2K is available for exploration as a graph that can be queried through a RESTful API addressing single entities or paths through their relationships. Practical use cases demonstrate its application to current knowledge inquiries.

CoV2K model, a comprehensive representation of SARS-CoV-2 knowledge and data interplay

Alfonsi, Tommaso;Al Khalaf, Ruba;Ceri, Stefano;Bernasconi, Anna
2022-01-01

Abstract

Since the outbreak of the COVID-19 pandemic, many research organizations have studied the genome of the SARS-CoV-2 virus; a body of public resources have been published for monitoring its evolution. While we experience an unprecedented richness of information in this domain, we also ascertained the presence of several information quality issues. We hereby propose CoV2K, an abstract model for explaining SARS-CoV-2-related concepts and interactions, focusing on viral mutations, their co-occurrence within variants, and their effects. CoV2K provides a clear and concise route map for understanding different connected types of information related to the virus; it thus drives a process of data and knowledge integration that aggregates information from several current resources, harmonizing their content and overcoming incompleteness and inconsistency issues. CoV2K is available for exploration as a graph that can be queried through a RESTful API addressing single entities or paths through their relationships. Practical use cases demonstrate its application to current knowledge inquiries.
2022
File in questo prodotto:
File Dimensione Formato  
s41597-022-01348-9.pdf

accesso aperto

: Publisher’s version
Dimensione 2.82 MB
Formato Adobe PDF
2.82 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1217446
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 5
social impact